CAPTURING THE COMPLEXITY OF THE HUMAN GUT
Altis Biosystems
Reproducible and scalable human intestine platform for ADME-Tox, DMPK & IBD studies
RepliGut® Systems
Altis Biosystems has pioneered the creation of Repligut® Systems, a collection of in vitro models derived from stem cells and designed specifically for pre-clinical drug discovery. RepliGut® models are designed to replicate the complex structure of the human small intestine and colonic epithelium using a standard user friendly format.
RepliGut models deliver valuable data insights, rapid screening capabilities, and an unparalleled biobank of ethically sourced donor intestinal cells, paving the way for more effective compound screening, disease modeling, and microbiome research.
Multiple Regions and Formats Available
RepliGut® Planar kits can include stem cells from any one of 5 distinct intestinal regions. They are all available in 12-well or 96-well transwell plates.
Small Intestine
- Duodenum
- Jejunum
Colon
- Ascending Colon
- Transverse Colon
- Descending Colon
RepliGut® Planar Model- How does it work?
Comparison with Caco-2
GI Toxicity
Screen compounds for drug-induced GI toxicity earlier in development
Intestinal Drug Disposition
Broaden bioavailability insights compared to Caco-2 cells
Intestinal Barrier Function
Characterize barrier integrity in response to challenges
Inflammatory Response
Evaluate pro- and anti- inflammatory effects of new modalities
InflammaScreen™ Services
Timeline
Assay Schematic
Readouts
